LRRK2 Rabbit Monoclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Sizes: 50µl, 100µl

Catalogue Numbers: BS40055-50, BS40055-100

Swiss-Prot: Q5S007

Host: Rabbit

LRRK2 Rabbit Monoclonal Antibody-BS40055

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat

Applications: WB, IHC ICC/IF, IP,

All Applications: WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

Background: Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.

Purification and Purity: Affinity-chromatography

Specificity: LRRK2 Antibody detects endogenous levels of total LRRK2

Bioworld Molecular Weight: 280kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of LRRK2 expression in U87-MG cell lysate., Immunohistochemical analysis of paraffin-embedded human thyroid, using LRRK2 Antibody.

Alternative Name: AURA17; Dardarin antibody; Leucine rich repeat kinase 2; LRRK 2 antibody; LRRK2; LRRK2_HUMAN; PARK 8; PARK8; RIPK7; ROCO 2; ROCO2;

Immunogen: A synthesized peptide derived from human LRRK2

Modification: Unmodified

Conjugate: Unconjugated