Do I need to prime or paint this before installing?

It comes primed, so you're good to bolt it on if you're keeping that finish. If you want color, paint after install or before—either way works. Just mask off any areas touching the frame.

Will this bolt directly onto my truck without drilling new holes?

Yes. It mounts at factory points, so no modification to your frame or existing hardware needed.

What hardware do I need to complete the install?

Fasteners aren't included with the panel. Check your truck's service manual or the hardware from your old fender—those bolts will work straight across.