Will this radiator work with my stock cooling fans and shroud?

Yes. This is a direct OEM replacement, so it mounts to the same factory attachment points. Your existing fan setup bolts straight on without modification.

Do I need to flush the system before installing this radiator?

Flush out old coolant before you install this. Fresh coolant protects the new core and prevents sediment buildup that can damage the aluminum.

Is this radiator pre-filled or do I need to bleed air from the system?

The radiator ships dry. Fill and bleed your cooling system following your vehicle's service manual procedure to remove air pockets after installation.